Editor’s Choice
Super-Resolution Track Density Imaging of Glioblastoma: Histopathologic Correlation • R.F. Barajas, Jr, C.P. Hess, J.J. Phillips, C.J. Von Morze, J.P. Yu, S.M. Chang, S.J. Nelson, M.W. McDermott, M.S. Berger, and S. Cha
Track density is a new imaging technique that allows submillimeter voxel resolution. These investigators used TDI to image 34 GBMs and correlated their findings with histopathology. TDI was elevated in tissues containing aggressive features and, regardless of contrast enhancement, these regions showed cellular proliferation, architectural disruption, and hypoxia. Thus, TDI may be helpful in identifying tumor infiltration in nonenhancing components of GBM.
Multimodal MR Imaging (Diffusion, Perfusion, and Spectroscopy): Is It Possible to Distinguish Oligodendroglial Tumor Grade and 1p/19q Codeletion in the Pretherapeutic Diagnosis? • S. Fellah, D. Caudal, A.M. De Paula, P. Dory-Lautrec, D. Figarella-Branger, O. Chinot, P. Metellus, P.J. Cozzone, S. Confort-Gouny, B. Ghattas, V. Callot, and N. Girard
These authors combined 3 advanced MRI techniques in an attempt to determine which oligodendrogliomas had 1p/19q deletions and thus a more favorable prognosis. They retrospectively analyzed data obtained in 50 tumors and found that though these 3 techniques were helpful in the grading of oligodendrogliomas, the multimodal approach used showed no significant differences between tumors with and without 1p/19q deletions.
Mystery of Chronic Cerebrospinal Venous Insufficiency: Identical Venographic and Ultrasound Findings in Patients with MS and Controls • W. McAuliffe and A.G. Kermode
Venous abnormalities as detected by sonography form the cornerstone of the hypothesis that they may be the cause of MS. These authors used high-resolution sonography to image neck vessels in 32 patients with MS and 10 controls using the Zamboni criteria. They found no differences were detected between patients and controls by using these criteria and that normal physiologic narrowing was very common in the internal jugular veins in controls.
Fellows’ Journal Club
Rate and Prognosis of Patients under Conscious Sedation Requiring Emergent Intubation during Neuroendovascular Procedures • A.E. Hassan, U. Akbar, S.A. Chaudhry, W.G. Tekle, R.P. Tummala, G.J. Rodriguez, and A.I. Qureshi
The purpose of this investigation was to determine the number of patients undergoing endovascular procedures under conscious sedation in whom general anesthesia and intubation were ultimately required. Of 520 subjects treated under conscious sedation, 9 (1.7%) required emergent intubation. This intubation had no effect on clinical outcome or in-hospital mortality.
Hyperintense Optic Nerve Heads on Diffusion-Weighted Imaging: A Potential Imaging Sign of Papilledema • R. Viets, M. Parsons, G. Van Stavern, C. Hildebolt, and A. Sharma
This retrospective review of 19 patients with papilledema and 20 controls sought to determine if optic nerve head DWI hyperintensity was present in the former group. The authors discovered that DWI optic nerve head hyperintensity was significantly associated with papilledema and that when bilateral it was 100% specific for it. Its absence, however, did not exclude papilledema.
Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy • D.S.T. Wong, K.J. Poskitt, V. Chau, S.P. Miller, E. Roland, A. Hill, and E.W.Y. Tam
In this study, prospective imaging was obtained in 179 term newborns with available glucose data. In these subjects, hypoxic-ischemic encephalopathy resulted in watershed, basal ganglia, total brain, and multifocal injury patterns. In 34 babies with hypoglycemia, selective involvement of posterior white matter and pulvinar edema were found. Conclusion: In term infants with hypoglycemia, specific imaging features for both hypoglycemia and hypoxia-ischemia can be identified.
