Feasibility of Permanent Stenting with Solitaire FR as a Rescue Treatment for the Reperfusion of Acute Intracranial Artery Occlusion

Fellows’ Journal Club

From January 2011 through January 2016, among 2979 patients with acute ischemic stroke, the authors identified 27 patients who underwent permanent stent placement (13 patients with the Solitaire FR and 14 patients with other self-expanding stents). The postprocedural modified TICI grade and angiographic and clinical outcomes were assessed. Stent placement was successful in all cases. Modified TICI 2b=3 reperfusion was noted in 84.6% of the Solitaire group and in 78.6% of the other stent group. They conclude that permanent stent placement with the Solitaire FR compared with other self-expanding stents appears to be feasible and safe as a rescue tool for refractory intra-arterial therapy.

Abstract

Figure 2 from paper
A 55-year-old man with acute ischemic stroke, presenting with an initial NIHSS score of 22. A, A right internal carotid angiogram shows occlusion of the right middle cerebral artery M1 portion. B, Initial placement of the Solitaire stent. A right internal carotid angiogram shows visible anterograde flow in the right middle cerebral artery M1 portion. C, A 5-minute delayed right internal carotid angiogram after thrombectomy using the Solitaire stent shows repeat buildup of thrombus and reocclusion. D, After 3 passages of the Solitaire stent with recurrent reocclusion, the decision for a permanent stent was made. A right internal carotid angiogram during the intravenous infusion of glycoprotein IIb/IIIa inhibitor shows a patent lumen of a temporarily deployed Solitaire stent. E, A 30-minute delayed angiogram after detachment of the Solitaire stent reveals complete recanalization. F, A follow-up angiogram at 3 months reveals a patent right middle cerebral artery with no evidence of in-stent restenosis at the M1 portion. The patient had an mRS score of 1 at 3 months.

BACKGROUND AND PURPOSE

The Solitaire FR can be used not only as a tool for mechanical thrombectomy but also as a detachable permanent stent. Our aim was to assess the feasibility and safety of permanent stent placement with the Solitaire FR compared with other self-expanding stents for intracranial artery recanalization for acute ischemic stroke.

MATERIALS AND METHODS

From January 2011 through January 2016, we retrospectively selected 2979 patients with acute ischemic stroke. Among them, 27 patients who underwent permanent stent placement (13 patients with the Solitaire FR [Solitaire group] and 14 patients with other self-expanding stents [other stent group]) were enrolled. The postprocedural modified TICI grade and angiographic and clinical outcomes were assessed. The safety and efficacy of permanent stent placement of the Solitaire FR for acute large-artery occlusion were evaluated.

RESULTS

Stent placement was successful in all cases. Modified TICI 2b–3 reperfusion was noted in 84.6% of the Solitaire group and in 78.6% of the other stent group. Procedural time was significantly shorter in the Solitaire group than in the other stent group (P = .022). Shorter procedural time was correlated with favorable outcome (ρ = 0.46, P = .035). No significant differences were found in the modified TICI grade, NIHSS score, mRS, and hemorrhagic transformation rate between the 2 groups. The acute in-stent thrombosis rate at discharge was significantly lower when a glycoprotein IIb/IIIa inhibitor was injected during the procedure (P = .013).

CONCLUSIONS

Permanent stent placement with the Solitaire FR compared with other self-expanding stents appears to be feasible and safe as a rescue tool for refractory intra-arterial therapy.

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Feasibility of Permanent Stenting with Solitaire FR as a Rescue Treatment for the Reperfusion of Acute Intracranial Artery Occlusion
Jeffrey Ross
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