Rubakhin SS, Sweedler JV, eds. Mass Spectrometry Imaging: Principles and Protocols. Methods in Molecular Biology, Vol 656. Humana Press 2010, 488 pages, 117 Illustrations, $139.00.

For those researchers in the neurosciences and those neuroradiologists who are deeply involved in advanced spectroscopic imaging, particularly in animal models, this book could serve as a reference text. After an introductory section on the basics of mass spectrometry (MS) and MS imaging, the book covers in sequence MS imaging of metabolites and pharmaceuticals and MS imaging of peptides and proteins. Methods for tissue preparation in addition to technical aspects related to image acquisition and display are present in virtually all chapters. Stained microscopic samples are included when appropriate. Clearly, this text is not intended for practicing radiologists, including those in academic medicine.