A 39-year-old man with history of tingling sensation on the left half of Face.

MRI revealed a solitary lesion in the splenium of the corpus callosum, hyperintense on T2/FLAIR and hypointense on T1W images. There is diffusion restriction.

This lesion was presumed demyelinating in view of h/o upper respiratory tract infection. At 6-week follow up MRI the lesion resolved completely.

Various etiologies have been reported for transient splenial lesions like:

• Seizures
• Sudden withdrawal of antiepileptic drugs
• Brain infarction
• Multiple sclerosis
• Cerebral trauma
• Neoplasm
• Adrenoleukodystrophy
• AIDS dementia complex
• Infections like influenza, measles, herpes,  Salmonella, mumps, adenovirus, varicella zoster, Legionnaires disease, rotavirus, HIV, tubercular meningitis
• Hypoglycemia
• Marchiafava-Bignami syndrome
• Hemolytic-uremic syndrome with encephalopathy

In absence of significant history of any of these conditions, how do we report this lesion and how often follow it up with MR?