Fellows’ Journal Club
September 2014
(1 of 3)
These authors found that increased cerebral blood flow and volume were seen in the basal ganglia of 4.3% of patients with ischemic strokes with CT perfusion. All patients had underlying MCA occlusions, 30% underwent hemorrhagic transformations, and the hyperperfused areas eventually became infarcted in all. Thus, acute basal ganglia hyperperfusion in patients with stroke may indicate nonviable parenchyma.
Abstract
BACKGROUND AND PURPOSE
CT perfusion scans are often used in acute stroke evaluations. We aimed to assess the outcome of areas of basal ganglia hyperperfusion on CTP in patients with acute ischemic stroke.
MATERIALS AND METHODS
We retrospectively reviewed the medical records and brain imaging of 139 patients presenting with acute stroke who underwent CTP for consideration of endovascular recanalization. Hyperperfusion was assessed qualitatively and defined as a matched region of increased cerebral blood flow and cerebral blood volume. CTA was used to locate arterial occlusion. Follow-up imaging was used to determine whether regions of hyperperfusion at baseline became infarcted or developed hemorrhage. Angiographic imaging was assessed to determine the presence or absence of early venous opacification.
RESULTS
Six patients (4.3%) demonstrated hyperperfusion in the basal ganglia of the affected side (4 in the lenticular nucleus and 2 in the caudate). In all cases, the area of hyperperfusion ultimately proved to be infarcted. All patients had received intravenous thrombolysis before the CTP. CTA at the time of CTP showed middle or distal M1 occlusion but patency of the proximal M1 and A1 segments. Intracranial hemorrhage was noted in 2 of these 6 patients at follow-up.
CONCLUSIONS
Acute basal ganglia hyperperfusion in patients with stroke may indicate nonviable parenchyma and risk of hemorrhagic conversion.
