Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas

Jeffrey Ross March 26, 2017March 24, 2017 Brain, Fellows' Journal Club

Fellows’ Journal Club The authors used DSC-MR imaging simulations to examine the influence of various acquisition parameters and leakage-correction strategies on the faithful estimation of CBV. Optimal strategies were determined by protocol with the lowest mean error. They conclude that

Evaluation of Encephaloduroarteriosynangiosis Efficacy Using Probabilistic Independent Component Analysis Applied to Dynamic Susceptibility Contrast Perfusion MRI

Jeffrey Ross March 25, 2017March 24, 2017 Brain, Editor's Choices

Editor’s Choice In this prospective study, 13 patients underwent unilateral indirect cerebral revascularization and DSC-MR imaging before and after surgery. Conventional perfusion parameters (relative CBV, relative CBF, and TTP) and probabilistic independent components that reflect the relative contributions of DSC

Synthetic MRI in the Detection of Multiple Sclerosis Plaques

Jeffrey Ross February 19, 2017February 17, 2017 Brain, Fellows' Journal Club

Fellows’ Journal Club In this retrospective study, synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced in 12 patients with MS after quantification of T1 and T2 values and proton density. Double inversion recovery images were

Quantifying Intracranial Plaque Permeability with Dynamic Contrast-Enhanced MRI: A Pilot Study

Jeffrey Ross February 18, 2017February 17, 2017 Brain, Editor's Choices

Editor’s Choice The purpose of this study was to use DCE MR imaging to quantify the contrast permeability of intracranial atherosclerotic disease plaques in 10 symptomatic patients and to compare these parameters against existing markers of plaque volatility using black-blood

Intracranial Arteriovenous Shunting: Detection with Arterial Spin-Labeling and Susceptibility-Weighted Imaging Combined

Jeffrey Ross January 22, 2017January 20, 2017 Brain, Fellows' Journal Club

Fellows’ Journal Club Ninety-two consecutive patients with a known (n = 24) or suspected arteriovenous shunting (n = 68) underwent DSA and brain MR imaging, including arterial spin-labeling/SWI and conventional angiographic MR imaging. DSA showed arteriovenous shunting in 63 of

Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T

Jeffrey Ross December 31, 2016December 19, 2016 Brain, Editor's Choices

Editor’s Choice Nineteen patients with schizophrenia and 11 matched healthy controls underwent MR imaging and multivoxel point-resolved 1H-MRS at 3T to obtain their hippocampal gray matter absolute NAA, Cr, and Cho concentrations. Patients’ average hippocampal GM Cr concentrations were 19%

Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in Relapsing-Remitting Multiple Sclerosis

Jeffrey Ross December 24, 2016December 19, 2016 Brain, Editor's Choices

Editor’s Choice Both dynamic susceptibility contrast perfusion with bookend T1-calibration and pseudocontinuous arterial spin-labeling have been used recently for CBF quantification in relapsing-remitting MS. The authors compared pseudocontinuous arterial spin-labeling CBF with the bookend technique in a prospective cohort of

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease

Jeffrey Ross December 18, 2016December 16, 2016 Brain, Fellows' Journal Club

Fellows’ Journal Club Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were evaluated. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers on both DSA and high-resolution

Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma

Jeffrey Ross December 17, 2016December 16, 2016 Brain, Editor's Choices

Editor’s Choice The authors explored regions of diffusion restriction following bevacizumab therapy in patients with glioblastoma by 1) analyzing tissue samples from patients at postmortem to pathologically confirm tumor cellularity or coagulative necrosis and 2) assessing the patient populationto determine

Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke

Jeffrey Ross November 26, 2016November 22, 2016 Brain, Editor's Choices

Editor’s Choice The authors set out to determine the agreement between collateral flow assessment on CTA and DSA and their respective associations with clinical outcome. They used patient data that was randomized in MR CLEAN with middle cerebral artery occlusion

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