Brain

Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange

Editor’s Choice The authors’ hypothesis is that incorporating bidirectional contrast agent transport into the DSC MR imaging signal model will improve rCBV estimates in brain tumors. A unidirectional contrast agent extravasation model (Boxerman-Weisskoff) was compared with a bidirectional contrast agent

Iron and Non-Iron-Related Characteristics of Multiple Sclerosis and Neuromyelitis Optica Lesions at 7T MR

Editor’s Choice Twenty-one patients with MS and 21 patients with neuromyelitis optica underwent 7T high-resolution 2D-gradient-echo-T2* and 3D-susceptibility-weighted imaging. An in-house-developed algorithm was used to reconstruct quantitative susceptibility mapping from SWI. Of the patients with MS, 19 (90.5%) demonstrated at

Mapping the Orientation of White Matter Fiber Bundles: A Comparative Study of Diffusion Tensor Imaging, Diffusional Kurtosis Imaging, and Diffusion Spectrum Imaging

Editor’s Choice The authors evaluated fiber bundle orientations from DTI and diffusional kurtosis compared with diffusion spectrum imaging as a criterion standard to assess the performance of each technique. DTI, diffusional kurtosis imaging, and diffusion spectrum imaging datasets were acquired

Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging

Editor’s Choice Twenty-eight patients with newly presenting glioblastoma multiforme underwent preoperative conventional imaging and T1 dynamic contrast-enhanced MRI. Parametric maps of the initial area under the contrast agent concentration curve, contrast transfer coefficient, estimate of volume of the extravascular extracellular

Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping

Editor’s Choice The authors evaluated 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls who underwent 3T MR imaging with a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility maps they measured the susceptibility values in the

A Spiral Spin-Echo MR Imaging Technique for Improved Flow Artifact Suppression in T1-Weighted Postcontrast Brain Imaging: A Comparison with Cartesian Turbo Spin-Echo

Editor’s Choice T1-weighted enhanced brain imaging was performed in 24 pediatric patients comparing the reference Cartesian TSE sequence (2 minutes 30 seconds) with a spiral spin-echo sequence (1 minutes 18 seconds) with similar spatial resolution and coverage. In 23/24 cases,