<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:wfw="http://wellformedweb.org/CommentAPI/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	xmlns:sy="http://purl.org/rss/1.0/modules/syndication/"
	xmlns:slash="http://purl.org/rss/1.0/modules/slash/"
	>

<channel>
	<title>cerebral blood volume &#8211; AJNR Blog</title>
	<atom:link href="https://www.ajnrblog.org/tag/cerebral-blood-volume/feed/" rel="self" type="application/rss+xml" />
	<link>https://www.ajnrblog.org</link>
	<description>The Official Blog of the American Journal of Neuroradiology</description>
	<lastBuildDate>Fri, 24 Mar 2017 21:07:09 +0000</lastBuildDate>
	<language>en-US</language>
	<sy:updatePeriod>
	hourly	</sy:updatePeriod>
	<sy:updateFrequency>
	1	</sy:updateFrequency>
	<generator>https://wordpress.org/?v=6.7.1</generator>
	<item>
		<title>Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas</title>
		<link>https://www.ajnrblog.org/2017/03/26/effects-mri-protocol-parameters-preload-injection-dose-fractionation-strategies-leakage-correction-algorithms-fidelity-dynamic-susceptibility-contrast-mri-estimates-relative-cer/</link>
		
		<dc:creator><![CDATA[jross]]></dc:creator>
		<pubDate>Sun, 26 Mar 2017 17:30:59 +0000</pubDate>
				<category><![CDATA[Brain]]></category>
		<category><![CDATA[Fellows' Journal Club]]></category>
		<category><![CDATA[cerebral blood volume]]></category>
		<category><![CDATA[DSC-MR imaging]]></category>
		<category><![CDATA[gliomas]]></category>
		<guid isPermaLink="false">http://www.ajnrblog.org/?p=12795</guid>

					<description><![CDATA[Fellows&#8217; Journal Club The authors used DSC-MR imaging simulations to examine the influence of various acquisition parameters and leakage-correction strategies on the faithful estimation of CBV. Optimal strategies were determined by protocol with the lowest mean error. They conclude that]]></description>
										<content:encoded><![CDATA[<div class="editor-comment">
<h1>Fellows&#8217; Journal Club</h1>
<p>The authors used DSC-MR imaging simulations to examine the influence of various acquisition parameters and leakage-correction strategies on the faithful estimation of CBV. Optimal strategies were determined by protocol with the lowest mean error. They conclude that the choice of image acquisition and preload dosing and/or fractionation has tremendous impact on the fidelity of CBV estimation. A variety of acquisition strategies can be used to obtain similar accuracy of CBV estimation, while the bidirectional leakage-correction algorithm aids in minimizing errors in CBV estimation under all scenarios.</p>
<p class="signature"><img decoding="async" src="http://www.ajnrblog.org/wp-content/uploads/ross-signature.png" alt="" /></p>
<p><span id="more-12795"></span></p>
</div>
<h2 class="signature">Abstract</h2>
<div id="sec-1" class="subsection">
<figure id="attachment_12796" aria-describedby="caption-attachment-12796" style="width: 300px" class="wp-caption alignright"><a href="http://www.ajnrblog.org/wp-content/uploads/F1.large-2.jpg"><img fetchpriority="high" decoding="async" class="wp-image-12796 size-medium" src="http://www.ajnrblog.org/wp-content/uploads/F1.large-2-300x203.jpg" alt="Figure 1 from paper" width="300" height="203" srcset="https://www.ajnrblog.org/wp-content/uploads/F1.large-2-300x203.jpg 300w, https://www.ajnrblog.org/wp-content/uploads/F1.large-2-150x101.jpg 150w, https://www.ajnrblog.org/wp-content/uploads/F1.large-2-630x426.jpg 630w, https://www.ajnrblog.org/wp-content/uploads/F1.large-2.jpg 1800w" sizes="(max-width: 300px) 100vw, 300px" /></a><figcaption id="caption-attachment-12796" class="wp-caption-text">Effect of the flip angle on recovery of CBV (TE = 35 ms/TR = 1.0 second). A, Percentage error (with 95% CI) of the estimated CBV for different flip angles and leakage-correction strategies, without the use of preload, compared with ground truth CBV. B, Percentage error (with 95% CI) of the estimated CBV for different flip angles and leakage-correction strategies, with use of ¼ dose preload, compared with ground truth CBV.</figcaption></figure>
<h3 id="p-3">BACKGROUND AND PURPOSE</h3>
<p>DSC perfusion MR imaging assumes that the contrast agent remains intravascular; thus, disruptions in the blood-brain barrier common in brain tumors can lead to errors in the estimation of relative CBV. Acquisition strategies, including the choice of flip angle, TE, TR, and preload dose and incubation time, along with post hoc leakage-correction algorithms, have been proposed as means for combating these leakage effects. In the current study, we used DSC-MR imaging simulations to examine the influence of these various acquisition parameters and leakage-correction strategies on the faithful estimation of CBV.</p>
<div id="sec-2" class="subsection">
<h3 id="p-4">MATERIALS AND METHODS</h3>
<p>DSC-MR imaging simulations were performed in 250 tumors with perfusion characteristics randomly generated from the distributions of real tumor population data, and comparison of leakage-corrected CBV was performed with a theoretic curve with no permeability. Optimal strategies were determined by protocol with the lowest mean error.</p>
</div>
<div id="sec-3" class="subsection">
<h3 id="p-5">RESULTS</h3>
<p>The following acquisition strategies (flip angle/TE/TR and contrast dose allocation for preload and bolus) produced high CBV fidelity, as measured by the percentage difference from a hypothetic tumor with no leakage: 1) 35°/35 ms/1.5 seconds with no preload and full dose for DSC-MR imaging, 2) 35°/25 ms/1.5 seconds with ¼ dose preload and ¾ dose bolus, 3) 60°/35 ms/2.0 seconds with ½ dose preload and ½ dose bolus, and 4) 60°/35 ms/1.0 second with 1 dose preload and 1 dose bolus.</p>
</div>
<div id="sec-4" class="subsection">
<h3 id="p-6">CONCLUSIONS</h3>
<p>Results suggest that a variety of strategies can yield similarly high fidelity in CBV estimation, namely those that balance T1- and T2*-relaxation effects due to contrast agent extravasation.</p>
</div>
<p><strong>Read this article: <a href="http://bit.ly/2nNHdfm">http://bit.ly/2nNHdfm</a></strong></p>
</div>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>Editor&#8217;s and Fellows&#8217; Journal Club Choices, October 2013</title>
		<link>https://www.ajnrblog.org/2013/10/09/editors-fellows-journal-club-choices-october-2013/</link>
		
		<dc:creator><![CDATA[MCastillo]]></dc:creator>
		<pubDate>Wed, 09 Oct 2013 20:37:33 +0000</pubDate>
				<category><![CDATA[Editor's Choices]]></category>
		<category><![CDATA[Fellows' Journal Club]]></category>
		<category><![CDATA[cerebral blood volume]]></category>
		<category><![CDATA[CT perfusion]]></category>
		<category><![CDATA[DTI]]></category>
		<category><![CDATA[DVA]]></category>
		<category><![CDATA[ischemic stroke]]></category>
		<category><![CDATA[MRI]]></category>
		<category><![CDATA[phase-sensitive MRI]]></category>
		<category><![CDATA[renal disease]]></category>
		<category><![CDATA[spinal cord metastases]]></category>
		<guid isPermaLink="false">http://www.ajnrblog.org/?p=7633</guid>

					<description><![CDATA[Editor&#8217;s Choices Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke • A.R. Jain, M. Jain, A.R. Kanthala, D. Damania, L.G. Stead, H.Z. Wang, and B.S. Jahromi Because hemorrhagic transformation affects treatment and patient prognosis, these authors explored whether]]></description>
										<content:encoded><![CDATA[<h2>Editor&#8217;s Choices</h2>
<p><strong><a title="Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke" href="http://www.ajnr.org/content/34/10/1895.full" target="_blank">Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke</a></strong> • <em>A.R. Jain, M. Jain, A.R. Kanthala, D. Damania, L.G. Stead, H.Z. Wang, and B.S. Jahromi</em><br />
Because hemorrhagic transformation affects treatment and patient prognosis, these authors explored whether CT perfusion predicts it. Twenty percent of their subjects developed hemorrhagic transformation and these patients did not differ from controls in terms of age, gender, time to presentation, or comorbidities. Only CBV was found to be lower and predictive of hemorrhagic transformation.</p>
<p><strong><a title="Parenchymal Hypointense Foci Associated with Developmental Venous Anomalies: Evaluation by Phase-Sensitive MR Imaging at 3T" href="http://www.ajnr.org/content/34/10/1940.full" target="_blank">Parenchymal Hypointense Foci Associated with Developmental Venous Anomalies: Evaluation by Phase-Sensitive MR Imaging at 3T</a></strong> • <em>M. Takasugi, S. Fujii, Y. Shinohara, T. Kaminou, T. Watanabe, and T. Ogawa</em><br />
These authors used phase-sensitive imaging to evaluate the presence of low-signal foci (hemorrhage or cavernoma) seen in association with developmental venous anomalies. More than 62% of patients with DVAs showed these foci, suggesting that venous congestion caused by abnormal venous drainage may be the cause and that phase-sensitive imaging is useful in their detection.</p>
<p><strong><a title="Widespread White Matter Alterations in Patients with End-Stage Renal Disease: A Voxelwise Diffusion Tensor Imaging Study" href="http://www.ajnr.org/content/34/10/1945.full" target="_blank">Widespread White Matter Alterations in Patients with End-Stage Renal Disease: A Voxelwise Diffusion Tensor Imaging Study</a></strong> • <em>M.-C. Chou, T.-J. Hsieh, Y.-L. Lin, Y.-T. Hsieh, W.-Z. Li, J.-M. Chang, C.-H. Ko, E.-F. Kao, T.-S. Jaw, and G.-C. Liu<br />
</em>Hemodyalisis may not prevent brain damage resulting from accumulation of urea and other metabolites as previously believed. These investigators used voxelwise DTI to assess the white matter of 28 patients with end-stage renal disease. All DTI parameters were abnormal, especially in the callosum, sagittal stratum, and pons.<em><br />
</em></p>
<h2>Fellows&#8217; Journal Club</h2>
<p><strong><a title="MR Imaging Features of Amyloid-Related Imaging Abnormalities" href="http://www.ajnr.org/content/34/10/1958.full" target="_blank">MR Imaging Features of Amyloid-Related Imaging Abnormalities</a></strong> • <em>J. Barakos, R. Sperling, S. Salloway, C. Jack, A. Gass, J.B. Fiebach, D. Tampieri, D. Melançon, Y. Miaux, G. Rippon, R. Black, Y. Lu, H.R. Brashear, H.M. Arrighi, K.A. Morris, and M. Grundman</em><br />
These authors used MR imaging studies from 210 patients being treated with bapineuzumab derived from 3 phase-2 studies to assess imaging abnormalities related to amyloidosis. Areas of edema and exudate/effusions were seen in 17% and hemosiderin deposition in 12%. Of those with significant hemosiderin deposition, nearly all had microhemorrhages and almost 50% of those with edema and exudate had hemosiderosis.</p>
<p><strong><a title="Incidental Findings in Youths Volunteering for Brain MRI Research" href="http://www.ajnr.org/content/34/10/2021.full" target="_blank">Incidental Findings in Youths Volunteering for Brain MRI Research</a></strong> • <em>R.E. Gur, D. Kaltman, E.R. Melhem, K. Ruparel, K. Prabhakaran, M. Riley, E. Yodh, H. Hakonarson, T. Satterthwaite, and R.C. Gur</em><br />
Incidental abnormalities seen in research MRI brain studies of 1400 “normal” volunteer individuals aged 8-23 years were assessed. Ten percent showed incidental findings and 12 of these required further follow-up. Findings were not related to age but whites had higher numbers of pineal cysts and males had a higher incidence of cavum septum pellucidum, which was associated with psychosis-related symptoms.</p>
<p><strong><a title="Intramedullary Spinal Cord Metastases: MRI and Relevant Clinical Features from a 13-Year Institutional Case Series" href="http://www.ajnr.org/content/34/10/2043.full" target="_blank">Intramedullary Spinal Cord Metastases: MRI and Relevant Clinical Features from a 13-Year Institutional Case Series</a></strong> • <em>J.B. Rykken, F.E. Diehn, C.H. Hunt, K.M. Schwartz, L.J. Eckel, C.P. Wood, T.J. Kaufmann, R.K. Lingineni, R.E. Carter, and J.T. Wald</em><br />
This article reviews the MRI and clinical findings in 70 spinal cord metastases; 20% of patients had multiple metastases and 8% were asymptomatic. Spinal cord metastases were the initial clinical presentation in 20% of patients. Nearly all metastases showed contrast enhancement and had extensive edema. Cysts and hemorrhage were, however, uncommon and nearly 60% of patients had other metastases to the CNS or that were seen in studies in other organs. Accompanying pial metastases were also common</p>
]]></content:encoded>
					
		
		
			</item>
	</channel>
</rss>