Fellows’ Journal Club Forty-seven patients with high-grade gliomas (primarily glioblastoma) with recurrent contrast-enhancing lesions on DSC-MR imaging were retrospectively evaluated after surgical sampling. Histopathologic examination defined treatment effect versus tumor. Normalized relative CBV thresholds of 1.0 and 1.75 were used
1. Zanier, E. R., Bertani, I., Sammali, E., Pischiutta, F., Chiaravalloti, M. A., Vegliante, G., … Chiesa, R. (2018). Induction of a transmissible tau pathology by traumatic brain injury. Brain, 2685–2699. https://doi.org/10.1093/brain/awy193 Traumatic brain injury is a risk factor for
Editor’s Choice The accuracy of DSC-MR imaging CBV maps in glioblastoma depends on acquisition and analysis protocols. The authors sought to compare the accuracy of routinely used protocols using a digital reference object that consisted of 10,000 simulated voxels recapitulating
Editor’s Choice A group of 133 patients with primary glioblastoma who underwent postcontrast T1-weighted imaging (acquired before treatment) and whose data were filed with the survival times were selected from the Cancer Genome Atlas. On the basis of overall survival,
Editor’s Choice Ninety-one localized biopsies were obtained from 36 patients with glioblastoma. Signal intensities corresponding to these samples were derived from T1-postcontrast subtraction, T2-FLAIR, and ADC sequences by using an automated coregistration algorithm. Cell density was calculated for each specimen
Editor’s Choice The authors explored regions of diffusion restriction following bevacizumab therapy in patients with glioblastoma by 1) analyzing tissue samples from patients at postmortem to pathologically confirm tumor cellularity or coagulative necrosis and 2) assessing the patient populationto determine
L.S. Politi Neuroimaging Research, Hematology/Oncology Division Boston Children’s Hospital/Dana Farber Cancer Institute Boston, Massachusetts Radiology Department University of Massachusetts Medical School Worcester, Massachusetts Neuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy G.
Editor’s Choice Twenty-eight patients with newly presenting glioblastoma multiforme underwent preoperative conventional imaging and T1 dynamic contrast-enhanced MRI. Parametric maps of the initial area under the contrast agent concentration curve, contrast transfer coefficient, estimate of volume of the extravascular extracellular
Please check out the accompanying podcast of this blog post (discussion of this article begins at 8:30) Glioblastoma is a heterogeneous group of cancers, genetically, molecularly and characteristically on imaging studies. Prior studies have supported the relationship between tumor location
Editor’s Choice Preoperative T1 anatomic MR images of 384 patients with glioblastomas were evaluated by an automated computational image-analysis pipeline to determine the anatomic locations of tumor in each patient. Voxel-based differences in tumor location between good and poor survival
