Feasibility of Brain Atrophy Measurement in Clinical Routine without Prior Standardization of the MRI Protocol: Results from MS-MRIUS, a Longitudinal Observational, Multicenter Real-World Outcome Study in Patients with Relapsing-Remitting MS

Jeffrey Ross March 3, 2018February 20, 2018 Brain, Editor's Choices

Editor’s Choice Brain atrophy outcomes of 590 patients were analyzed by the percentage brain volume change measured by structural image evaluation with normalization of atrophy on 2D-T1WI and 3D-T1WI and the percentage lateral ventricle volume change, measured by VIENA on

Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study

Jeffrey Ross October 17, 2017October 17, 2017 Brain, Editor's Choices

Editor’s Choice Brain dual-echo, 3D T1-weighted, and double inversion recovery scans were acquired at 3T from 62 patients with relapsing-remitting MS and 65 controls. Focal WM and cortical lesions were identified, and volumetric measures from WM, cortical GM, the hippocampus,

Neuroimaging Clinics of North America: Advances in Imaging of Multiple Sclerosis

Book Reviews September 22, 2017September 22, 2017 Book Reviews, Books Briefly Noted

Mukherji SK, ed. Rovira À, consulting ed. Neuroimaging Clinics of North America: Advances in Imaging of Multiple Sclerosis. Elsevier; 2017;27(2):195–370; $365.00 MRI is often performed for a suspicion of multiple sclerosis or for follow-up in patients known to have MS.

Heterogeneity of Cortical Lesion Susceptibility Mapping in Multiple Sclerosis

Jeffrey Ross June 17, 2017June 16, 2017 Brain, Editor's Choices

Editor’s Choice The authors characterized the susceptibility mapping of cortical lesions in patients with MS (n=36) and compared it with neuropathologic observations (n=16). Neuropathologic analysis revealed the presence of an intense band of microglia activation close to the pial membrane

Synthetic MRI in the Detection of Multiple Sclerosis Plaques

Jeffrey Ross February 19, 2017February 17, 2017 Brain, Fellows' Journal Club

Fellows’ Journal Club In this retrospective study, synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced in 12 patients with MS after quantification of T1 and T2 values and proton density. Double inversion recovery images were

Magnetic Susceptibility from Quantitative Susceptibility Mapping Can Differentiate New Enhancing from Nonenhancing Multiple Sclerosis Lesions without Gadolinium Injection

Jeffrey Ross October 22, 2016October 21, 2016 Brain, Editor's Choices

Editor’s Choice In 54 patients, new T2-weighted lesions were evaluated for enhancement on conventional T1-weighted imaging with gadolinium, and their susceptibility values were measured on quantitative susceptibility mapping. Eighty-six of 133 new lesions that were gadolinium-enhancing had relative susceptibility values

Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation

Jeffrey Ross September 24, 2016September 23, 2016 Brain, Editor's Choices

Editor’s Choice The authors characterized lesion changes on quantitative susceptibility mapping and R2* at various gadolinium enhancement stages (nodular, shell-like, nonenhancing) in 64 patients with 203 lesions. They found that: 1) active MS lesions with nodular enhancement show R2* decrease

Evaluation of Focal Cervical Spinal Cord Lesions in Multiple Sclerosis: Comparison of White Matter–Suppressed T1 Inversion Recovery Sequence versus Conventional STIR and Proton Density–Weighted Turbo Spin-Echo Sequences

Jeffrey Ross September 4, 2016September 2, 2016 Fellows' Journal Club, Spine

Fellows’ Journal Club The authors performed a retrospective blinded analysis of cervical cord MR imaging examinations of 50 patients with MS. In each patient, 2 neuroradiologists measured the number of focal lesions and overall lesion conspicuity in the STIR/proton density–weighted

Cortical Perfusion Alteration in Normal-Appearing Gray Matter Is Most Sensitive to Disease Progression in Relapsing-Remitting Multiple Sclerosis

Jeffrey Ross August 27, 2016August 26, 2016 Brain, Editor's Choices

Editor’s Choice Bookend perfusion was used to quantify parameters in normal-appearing and lesional tissue at different relapsing-remitting MS stages in 39 patients and 19 age-matched healthy controls. Perfusion parameters such as CBF, CBV, and MTT were compared along with cognitive

Iron and Non-Iron-Related Characteristics of Multiple Sclerosis and Neuromyelitis Optica Lesions at 7T MR

Jeffrey Ross July 30, 2016August 18, 2016 Brain, Editor's Choices

Editor’s Choice Twenty-one patients with MS and 21 patients with neuromyelitis optica underwent 7T high-resolution 2D-gradient-echo-T2* and 3D-susceptibility-weighted imaging. An in-house-developed algorithm was used to reconstruct quantitative susceptibility mapping from SWI. Of the patients with MS, 19 (90.5%) demonstrated at

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